Thermo Fisher Scientific PDE6B Polyclonal Antibody
Rabbit polyclonal antibody targeting human PDE6B. Validated for IHC (paraffin) with high specificity. Supplied as a liquid, unconjugated form in PBS with glycerol. Ideal for research on cAMP/cGMP signaling and visual transduction pathways.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PDE6B. Recombinant protein control fragment (Product #RP-106511) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662822 |
Product Specific Information
Immunogen sequence:
DRDEIQLILPT RARLGKEPAD CDEDELGEIL KEELPGPTTF DIYEFHFSDL
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in a wide variety of signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and degradation by cyclic nucleotide phosphodiesterases (PDEs).
PDE6 acts as the effector enzyme in the G protein-mediated signal transduction cascade of the visual system. It consists of multiple subunits:
- Catalytic subunits: α′ (Cone), α (Rod), β (Rod)
- Inhibitory subunit: γ
- Additional subunit δ (likely interacts with other proteins)
The catalytic core forms:
- α′/α′ homodimers in cones
- α/β heterodimers in rods
C-terminal modifications such as methylation, myristoylation, and prenylation are critical for proper complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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