Thermo Fisher Scientific NCALD Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NCALD.

Target Information

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium-binding loops. It is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-Golgi network. The protein is thought to regulate G protein-coupled receptor signal transduction. Several alternatively spliced variants have been identified, all encoding the same protein; additional variants may exist but their biological validity remains undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.