Thermo Fisher Scientific ErbB 4 Polyclonal Antibody, Biotin
ErbB4 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체로, Western blot, IHC, ELISA, IP 등에 사용 가능. Human, Mouse, Rat 반응성. Affinity chromatography로 정제되었으며, -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- HER4-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1225–1275 on human Receptor tyrosine-protein kinase ErbB-4 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors, inducing various cellular responses such as mitogenesis and differentiation.
It acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation. Like other protein kinases, ErbB4 regulates signal transduction in eukaryotic cells, influencing metabolism, transcription, cell cycle, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
ErbB4 is highly expressed in several breast carcinoma cell lines (T47-D, MDA-MB-453, BT-474, H3396) and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Intermediate expression is observed in MCF-7, MDA-MB-330, and MDA-MB-361, while low or absent expression is found in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. Elevated ErbB4 levels in certain tumor cell lines suggest a potential role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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