Thermo Fisher Scientific GSTA3 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: SSLISNFPLL KALKTRISNL PTVKKFLQPG SPRKPPADAK ALEEARKIFR
• Sequence homology: Human 100%; Mouse 79%; Sheep 77%

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes participate in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the alpha class, located on chromosome 6. Alpha class genes encode enzymes with glutathione peroxidase activity, though evolutionary divergence has led to differences in substrate specificity and catalytic activity. The enzyme catalyzes the double bond isomerization of precursors for progesterone and testosterone during steroid hormone biosynthesis. An additional transcript variant has been identified, though its full-length sequence has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.