Thermo Fisher Scientific GSTM5 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence:
  MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK

• Sequence homology:
  Cow: 93%
  Dog: 93%
  Goat: 93%
  Guinea Pig: 85%
  Horse: 93%
  Human: 100%
  Mouse: 86%
  Pig: 100%
  Rabbit: 85%
  Rat: 86%

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products, by conjugation with glutathione.
The mu class genes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic, affecting susceptibility to toxins and drug responses. Diversification has occurred in substrate-binding domains and tissue expression patterns to accommodate numerous foreign compounds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.