Thermo Fisher Scientific Syk Polyclonal Antibody
Rabbit polyclonal antibody targeting human Syk protein for immunohistochemistry (paraffin). Antigen affinity purified, unconjugated, supplied as liquid in PBS with glycerol. Ideal for research on allergic, autoimmune, and cancer signaling pathways.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Syk (Product #RP-95942) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856041 |
Immunogen Sequence
GLLRVLTVPC QKIGTQGNVN FGGRPQLPGS HPATWSAGGI ISRIKSYSFP KPGHRKSSPA QGNRQESTVS FNPYEPELAP WAADKGPQRE ALPMDTEVYE SPYADPEEIR PKEVYLDRKL LTLEDKELGS GNF
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its pair of SH2 domains with ITAM motifs of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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