Thermo Fisher Scientific Aurora A Monoclonal Antibody (35C1)
Aurora A 단백질을 인식하는 mouse monoclonal antibody (clone 35C1). Western blot, ICC/IF, IP에 적합하며 다양한 종에 반응. Protein A로 정제된 액상 형태로, 0.5 mg/mL 농도. 암 연구 및 세포주기 조절 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 5 publications |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL | View 1 publication |
| Immunoprecipitation (IP) | 5 µg | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Category | Details |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Human, Mouse, Non-human primate, Pig, Rat |
| Published Species | Hamster, Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 35C1 |
| Immunogen | Recombinant protein derived from the full length of human Aurora A Kinase (UniProt ID: O14965-1, amino acids 1–403) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533839 |
Available Conjugated Formats
Target Information
Gene/Protein: AURKA (Aurora A)
Function: Aurora A is a serine/threonine kinase that regulates mitosis by associating with centrosomes. It plays a key role in cell cycle regulation during anaphase and telophase, particularly in chromosome segregation at the centrosome/spindle pole region.
Clinical Relevance: Overexpression of Aurora A is observed in various cancers including breast, ovarian, and colorectal cancers. It is considered a potential target for anticancer drug development.
Tissue Specificity: Highly expressed in testis; weakly expressed in skeletal muscle, thymus, and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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