Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI4C5), TrueMAB
인간 ACE2 단백질을 인식하는 마우스 단클론 항체로, Western blot과 면역조직화학에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태이며 안정적 저장 버퍼 포함. 연구용으로 SARS-CoV 관련 수용체 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of human ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 also functions as a receptor for the SARS coronavirus. Physiologically, ACE2 converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, whereas ACE converts AngI to AngII. The absence of ACE2 expression in knockout mice leads to reduced cardiac contractility, indicating its critical role in heart function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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