Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI2G7), TrueMAB
ACE2 단백질을 인식하는 Mouse monoclonal 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 인간 ACE2(aa 18-237) 재조합 단백질로 면역한 TrueMAB 제품입니다. 고순도 Affinity chromatography 정제, 액상 형태로 -20°C 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of human ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to the heart, kidney, and testis. ACE2 has also been identified as a functional receptor of the SARS coronavirus.
ACE2 converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
Lack of ACE2 expression in ace2⁻/⁻ mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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