Thermo Fisher Scientific CRTH2 Polyclonal Antibody
CRTH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 적합하며 인간 및 마우스 반응성. 항원 친화 크로마토그래피로 정제된 고순도 제품으로 알레르기 및 Th2 면역 반응 연구에 유용.
- 카탈로그번호
- PA534502
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CRTH2 Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | - |
| Immunohistochemistry (IHC) | 20 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Neutralization (Neu) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the center of human PTGDR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551854 |
Product Specific Information
- Suggested positive control: human small intestine tissue lysate
- PA5-34502 can be used with blocking peptide PEP-1545
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells and acts as a receptor for prostaglandin D2 (PGD2). It mediates chemotaxis of Th2 cells and eosinophils toward PGD2, playing a key role in allergic responses.
CRTH2-deficient mice show enhanced eosinophil recruitment and increased IL-5 and IL-3 production, suggesting its role in restricting eosinophilia and allergic responses.
CRTH2 is a member of the G protein-coupled leukocyte chemoattractant receptor family, selectively expressed in Th2 lineage cells. It is found in the central nervous system, peripheral tissues, and activated T helper-2 cells.
Two transcripts have been identified:
- 3.5 kb transcript: expressed in thalamus, frontal cortex, pons, hippocampus
- 3.4 kb transcript: expressed in fetal liver, leukocytes, thymus
CRTH2 expression is associated with activated Th2 cells, suggesting its pivotal role in Th2-type immune reactions. Single nucleotide polymorphisms in the 3′ UTR of the CRTH2 gene have been linked to asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.