Thermo Fisher Scientific PNAS4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MGANQLVVLN VYDMYWMNEY TSSIGIGVFH SGIEVYGREF AYGGHPYPFS GIFEISPGNA SELGETFKFK EAVVLGSTDF LEDDIEKIVE ELGKEYKGNA YHLMHKNCNH FSSALSEILC GKEIPRWINR LAYFSSCIPF LQSCLPKEWL TPAALQSSVS QELQDELEEA EDAAASASVA STAAGSRPGR HTKL

Target Information

PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4.
PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in tumor cells such as U2OS, SKOV3, and A549.

Mechanisms of action:

1. Overexpression of PNAS4 causes S phase arrest by regulating cell cycle-related proteins.
2. PNAS4 induces apoptosis through the mitochondrial pathway.

Recent studies suggest that PNAS4 may play a role in cancer genesis and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine.
At least two isoforms of PNAS4 are known to exist.

⚠ WARNING:
This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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