Thermo Fisher Scientific PON1 Polyclonal Antibody
PON1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. Human 및 Mouse 시료에 반응하며, Affinity chromatography로 정제됨. PBS와 50% glycerol에 보관되며, -20°C에서 저장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PON1 (Accession P27169), corresponding to amino acid residues I57–F107 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900415 |
Product Specific Information
This antibody detects endogenous levels of total PON1.
Target Information
The paraoxonase (PON) gene family in humans has three members: PON1, PON2, and PON3, aligned on chromosome 7q21.3–22.1.
PON1 is synthesized primarily in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of several organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphism may contribute to neurodegeneration and is considered an independent risk factor for Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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