Thermo Fisher Scientific PDE12 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PDE12. Validated for Western blot with high specificity. Suitable for detecting PDE12 in human, rat, mouse, and bovine samples. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Predicted Reactivity | Rat, Mouse, Bovine |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 559–609 of human 2’,5’-phosphodiesterase 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7.0–8.0 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Predicted reactivity by homology includes Rat, Mouse, and Bovine.
Target Information
PDE12 is an enzyme that cleaves the 2’,5’-phosphodiester bond linking adenosines of triphosphorylated oligoadenylates (2-5A), modulating the 2-5A system. This enzyme degrades triphosphorylated 2-5A to produce AMP and ATP, and also cleaves 3’,5’-phosphodiester bonds of oligoadenylates. PDE12 acts as a negative regulator of the 2-5A system, a key antiviral and antitumor pathway induced by interferons (IFNs). Suppression of PDE12 reduces viral replication in HeLa cells, likely by inhibiting the 2-5A system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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