Thermo Fisher Scientific PDE12 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PDE12. Validated for Western blot with dilution range 1:2,000–1:10,000. Predicted cross-reactivity with rat, mouse, and bovine. Supplied as 1 mg/mL liquid, stored at 4°C, shipped on wet ice.
- 카탈로그번호
- A305637Ax (2개 옵션)
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 559 to 609 of human 2',5'-phosphodiesterase 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Predicted reactivity by homology: Rat, Mouse, Bovine.
Target Information
PDE12 is an enzyme that cleaves the 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates (2-5A), which modulates the 2-5A system.
This enzyme degrades triphosphorylated 2-5A to produce AMP and ATP.
It also cleaves the 3',5'-phosphodiester bond of oligoadenylates and functions as a negative regulator of the 2-5A system — one of the major pathways for antiviral and antitumor responses induced by interferons (IFNs).
Suppression of PDE12 reduces viral replication in HeLa cells, suggesting it counteracts antiviral pathways by inhibiting the 2-5A system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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