Thermo Fisher Scientific Phospho-Bcl-X (Thr47) Polyclonal Antibody
Rabbit Polyclonal Antibody로, 인산화된 Bcl-X (Thr47) 단백질을 특이적으로 인식합니다. Western blot, IHC(P), ICC/IF에 사용 가능하며, 액상 형태로 제공됩니다. 연구용으로 세포 사멸 관련 신호전달 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human BCL-XL around the phosphorylation site of Thr47 (M-E-TP-P-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555011 |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. These proteins are located at the outer mitochondrial membrane and regulate the opening of the voltage-dependent anion channel (VDAC). VDAC controls mitochondrial membrane potential, production of reactive oxygen species, and release of cytochrome C, all of which are key factors in apoptosis induction. Alternative splicing results in multiple transcript variants encoding two isoforms: the longer isoform acts as an apoptotic inhibitor, whereas the shorter isoform functions as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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