Thermo Fisher Scientific MEK1 Polyclonal Antibody
MEK1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA에 적합합니다. Human, Mouse, Rat에 반응하며 액상 형태로 제공됩니다. Affinity Chromatography로 정제되었으며, 세포 성장 및 분화 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 1–100 of human MEK1 (NP_002746.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805079 |
Product Specific Information
Immunogen sequence:
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH
Positive Samples:
Jurkat, HeLa, A-431, MCF-7, Mouse Liver, Mouse Kidney, Rat Thymus
Cellular Location:
Cytoplasm, Membrane, Nucleus, Peripheral membrane protein, Centrosome, Cytoskeleton, Microtubule organizing center, Spindle pole body
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by various growth factors, cytokines, and membrane-dependent depolarization and calcium influx. MEK1 activation occurs via phosphorylation of serine 218 and 222 residues by Raf1. It is involved in stress response, apoptosis, and cytokine-induced proliferation. Mutations in this gene can lead to cardiofaciocutaneous syndrome.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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