Thermo Fisher Scientific QKI Polyclonal Antibody
Thermo Fisher Scientific의 QKI Polyclonal Antibody는 Western blot, IHC, IP 등에 적합한 Rabbit Polyclonal 항체입니다. 다양한 종에 반응이 예측되며, 액상 형태로 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A300183Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific QKI Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:25,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-terminus of isoform 5 of Human quaking homolog (QKI, UniProt ID: Q96PU8-1, antigen length: 341 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
- Predicted to react with Rat, Zebrafish, Xenopus laevis, Chicken, Bovine, Dog, Horse, Pig, and Cat based on sequence identity.
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. It is highly expressed in the central nervous system, as well as in skin, skeletal muscles, and at low levels in the pancreas. The gene includes a large exon spanning more than 12.8 kb. Mutations result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin is known to protect against mutant ataxin-1. A pseudogene is located on chromosome 11, and alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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