Thermo Fisher Scientific SMAD4 Monoclonal Antibody (4G1C6)
SMAD4 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. 인간 및 마우스 반응성. 비결합형 액상 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
| in situ PLA (PLA) | - | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G1C6 |
| Immunogen | Purified recombinant fragment of human SMAD4 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10986059 |
Product Specific Information
MA5-15682 targets SMAD4 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human SMAD4 expressed in E. coli.
MA5-15682 detects SMAD4, which has a predicted molecular weight of approximately 65 kDa.
Target Information
Smad4 is encoded by the SMAD4 gene located on chromosome 18 in humans. It is also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 and C-terminal MH2 globular domains involved in DNA binding and protein interactions. Upon activation by TGF-β or BMP ligands, receptor Smads (R-Smads) are phosphorylated and form complexes with Smad4 (co-Smad), which translocate to the nucleus to regulate gene expression.
Smad4 functions as a tumor suppressor by modulating transcription of genes such as Cyclin D1 (downregulation) and collagen (upregulation), affecting cell proliferation. Dephosphorylation controls nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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