Thermo Fisher Scientific STIM2 Polyclonal Antibody, FITC
STIM2 단백질을 인식하는 FITC 결합 폴리클로날 항체로 Western blot, ELISA, IP에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제. 형광 최대치 498/517 nm, 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 600–650 on human STIM2 protein |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are composed of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca++ sensor and activates the CRAC channels by migrating to the plasma membrane from ER-like sites serving as Ca++ stores.
A related molecule, STIM2, inhibits STIM1-mediated store-operated Ca++ entry and can form complexes with STIM1, suggesting a coordinated role in Ca++ regulation. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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