Thermo Fisher Scientific STIM2 Polyclonal Antibody, Biotin
STIM2 단백질을 인식하는 Biotin-conjugated Rabbit Polyclonal Antibody. Western blot, ELISA, Immunoprecipitation에 적합. Human, Mouse, Rat 시료 반응성. Affinity chromatography로 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 600–650 of human STIM2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In T lymphocytes, the sole pathway for Ca²⁺ entry following antigen-receptor binding is through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels consist of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca²⁺ sensor and activates CRAC channels by migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites. A related molecule, STIM2, inhibits STIM1-mediated store-operated Ca²⁺ entry and can form complexes with STIM1, suggesting a coordinated role in Ca²⁺ regulation. At least three isoforms of STIM2 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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