Thermo Fisher Scientific MLK4 Polyclonal Antibody
Thermo Fisher Scientific의 MLK4 Polyclonal Antibody는 인간 MLK4 단백질을 인식하는 토끼 IgG 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 0.2 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MLK4. Recombinant protein control fragment (Product # RP-89790) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644003 |
Product Specific Information
Immunogen sequence:
GNPTPTGATI ISATGASALP LCPSPAPHSH LPREVSPKKH STVHIVPQRR PASLRSRSDL PQAYPQTAVS QLAQTACVVG RPGPHPTQFL AAKERTKSHV PSLLDADVEG QSRDYTVPLC RMRSKTSRPS IYELEKE
Highest antigen sequence identity to orthologs:
- Mouse: 33%
- Rat: 34%
Target Information
MLK4 (Mixed Lineage Kinase 4) belongs to the MAP kinase kinase kinase (MAP3K) superfamily, containing both serine/threonine and tyrosine kinase activity in its catalytic domains.
The structure includes:
- N-terminal Src homology (SH3) domain
- Kinase domain
- Leucine zipper region
- CDC42/RAC-interactive binding (CRIB) motif
- Divergent C-terminal regions
MLK4 is highly expressed in kidney and pancreas. It acts as a negative regulator of TLR4 and does not activate JNK1/MAPK8, p38/MAPK14, or ERK2/MAPK1 pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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