Thermo Fisher Scientific 14-3-3 zeta Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Jurkat, HeLa, A-549, MCF7, Mouse brain, Mouse lung, Rat brain
• Cellular Location: Cytoplasm, Melanosome

Immunogen sequence:
QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EKACSLAKTA FDEAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDTQGD EAEAGEGGEN

Target Information

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3 proteins are key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis. Other proteins that bind to 14-3-3s include protein kinase C family members, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf, and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.