Thermo Fisher Scientific 14-3-3 zeta Polyclonal Antibody
인간, 마우스, 랫트에서 반응하는 14-3-3 zeta 단백질에 대한 토끼 폴리클로날 항체. Western blot 및 ELISA에 적합. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 제공. PBS/glycerol buffer에 보존하며 -20°C에서 보관.
- 카탈로그번호
- PA589197
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 146–245 of human YWHAZ (NP_001129171.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805411 |
Product Specific Information
- Positive Samples: Jurkat, HeLa, A-549, MCF7, Mouse brain, Mouse lung, Rat brain
- Cellular Location: Cytoplasm, Melanosome
Immunogen sequence:
QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EKACSLAKTA FDEAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDTQGD EAEAGEGGEN
Target Information
At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3 proteins are key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with Bad, prevents apoptosis. Other proteins that bind to 14-3-3s include protein kinase C family members, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf, and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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