Thermo Fisher Scientific SAFB1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SAFB1 protein. Validated for WB, IHC, IHC-P, and IP applications. Recommended dilution ranges from 1:100 to 1:10,000. Unconjugated liquid form with 0.20 mg/mL concentration. Suitable for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 775 and 825 of Human Scaffold Attachment Factor B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
This gene encodes a DNA-binding protein with high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). It is thought to anchor chromatin loops to the nuclear matrix, although evidence is mixed regarding its exact role. Scaffold attachment factors form a subset of nuclear matrix proteins that bind S/MAR sequences. The encoded protein may serve as a molecular base for assembling a transcriptosome complex near actively transcribed genes. It regulates heat shock protein 27 transcription, acts as an estrogen receptor co-repressor, and is implicated in breast tumorigenesis. The gene is arranged head-to-head with a similar gene encoding a protein of comparable function. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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