Thermo Fisher Scientific SQLE Polyclonal Antibody
SQLE 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 검증됨. 인간 반응성, 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 콜레스테롤 합성 연구용에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human SQLE (aa 451–500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607850 |
Product Specific Information
- Peptide sequence: KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE
- Sequence homology:
Cow: 100% / Dog: 93% / Guinea Pig: 86% / Horse: 86% / Human: 100% / Mouse: 100% / Pig: 93% / Rabbit: 100% / Rat: 93% / Sheep: 100% / Zebrafish: 86%
Target Information
SQLE (Squalene Epoxidase), also known as ERG1, SE, and SM, belongs to the squalene monooxygenase family.
It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure.
SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, rate-limiting enzyme).
It is post-translationally regulated by cholesterol-dependent proteasomal degradation.
The molecular weight (MW) of SQLE is approximately 64 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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