ELK Biotechnology FILA rabbit pAb
FILA rabbit pAb는 인간, 생쥐, 랫트에 반응하는 polyclonal 항체로, IHC 및 IF 실험에 적합합니다. 인간 단백질 유래 합성 펩타이드로 면역화되었으며, 세포질 과립 및 표피 각질형성세포에서 발현되는 필라그린 단백질 검출에 사용됩니다.
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제품명
FILA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 446 kDa |
| GeneID (Human) | 2312 |
| Human Swiss-Prot No | P20930 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasmic granule. In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719).
배경 (Background)
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. [provided by RefSeq, Dec 2009]
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