Thermo Fisher Scientific PAGR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PAGR1. Recombinant protein control fragment (Product #RP-98795). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PAGR1,uniProtId:Q9BTK6-1,ncbiNodeId:9606,antigenRange:163-252,antigenLength:254,antigenImageFileName:PA5-60436_PAGR1_Q9BTK6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60436_PAGR1_Q9BTK6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645173

Product Specific Information

Immunogen sequence: HMPTEFDFDD EPVTPKDSLI DRRRTPGSSA RSQKREARLD KVLSDMKRHK KLEEQILRTG RDLFSLDSED PSPASPPLRS SGSSLFPRQR

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 98%.

Target Information

Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.