Thermo Fisher Scientific CYP11B1 Polyclonal Antibody
Human CYP11B1 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC 및 IHC(Paraffin) 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 글리세롤로 안정화. 연구용으로만 사용되며, 장기 보관 시 -20°C에서 보관 권장.
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- PA563290
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: -
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CYP11B1. Recombinant protein control fragment (Product #RP-104168). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640314 |
Product Specific Information
Immunogen sequence:
RFLPMVDAVA RDFSQALKKK VLQNARGSLT LDVQPSIFHY TIEASNLALF GERLGLVGHS PSSASLNFLH ALEVMFKSTV QLMFMPR
Sequence identity to orthologs:
- Mouse: 71%
- Rat: 72%
Target Information
The steroid 11beta-hydroxylase gene (CYP11B1) is a marker for functional differentiation of cells in the zonae fasciculata reticularis.
The deduced CYP11B1 protein (466 amino acids) includes a secretory signal, EGF-like repeats, and a proteolytically inactive cathepsin B-related sequence.
Human aldosterone synthase (CYP11B2) is related and involved in substrate recognition and conversion.
A chimeric gene duplication between CYP11B1 and CYP11B2 causes glucocorticoid-remediable aldosteronism, characterized by hyperaldosteronism and elevated 18-hydroxycortisol and 18-oxocortisol under ACTH control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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