Thermo Fisher Scientific EVER2 Polyclonal Antibody
EVER2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성 보유. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA599731
- 판매단위
- pk
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Applications
Western Blot (WB)
Immunocytochemistry (ICC/IF)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TMC8 (Accession Q8IU68), corresponding to amino acid residues S683–L726 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818664 |
Product Specific Information
Antibody detects endogenous levels of total TMC8.
Target Information
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses.
Mutations in two homologous genes, EVER1 and EVER2, cause the majority of EV cases. These proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum.
Cells lacking EVER2 accumulate higher levels of zinc in the nucleolus and nucleus compared to those with an intact EVER2 gene, indicating that one role of EVER2 is to regulate intracellular zinc distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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