Thermo Fisher Scientific PRRX1 Polyclonal Antibody
PRRX1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western Blot 및 IHC(P) 등에 사용 가능하며, 인간과 마우스 반응성 확인. 액상 형태로 제공되며 안정적인 저장 및 높은 특이성 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (GSDTPQQDNDQ) corresponding to the internal amino acids of PRRX1 (aa 73–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981765 |
Product Specific Information
- This antibody is predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 2,000.
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species, functioning to bind DNA via a helix-turn-helix structure and playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid nuclear protein containing one OAR domain and one homeobox DNA-binding domain. It acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to mesodermal muscle type establishment. PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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