Thermo Fisher Scientific FABP5 Monoclonal Antibody (CPTC-FABP5-3)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

FABP5 (fatty acid binding protein 5, psoriasis-associated) is encoded by the FABP5 gene, also known as PAFABP, EFABP, E-FABP, KFABP, PA-FABP, Epidermal-type fatty acid-binding protein, and Psoriasis-associated fatty acid-binding protein homolog.
This family consists of small, highly conserved cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. The PAFABP cDNA encodes a 135-amino acid protein with a molecular weight of approximately 15,164 Da.
FABP5 is primarily expressed in epidermal cells and is upregulated in psoriatic tissue. Its roles include fatty acid uptake, transport, and metabolism.
Kaczocha et al. (2009) identified FABP5 and FABP7 as cytosolic proteins that transport AEA from the plasma membrane to subcellular fatty acid amide hydrolase, where AEA is hydrolyzed and inactivated. FABP3 did not show this specific transport function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.