Thermo Fisher Scientific RNASE3 Polyclonal Antibody
RNASE3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western Blot, IHC, ELISA에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Ribonuclease 3 aa 1–50/160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932435 |
Product Specific Information
- Application notes: Indirect ELISA
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein belonging to the pancreatic ribonuclease family.
ECP localizes to the granule matrix of eosinophils and plays a role in the immune response system. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils.
ECP exhibits anti-parasitic, antibacterial, and ribonucleolytic activities. It has been associated with the neurotoxic Gordon phenomenon, characterized by ataxia, muscular rigidity, paralysis, and tremor.
ECP serves as a marker of eosinophilic inflammation, with elevated levels observed in active asthma and other allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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