Thermo Fisher Scientific LYRIC Polyclonal Antibody
Metadherin(MTDH/LYRIC) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, Flow 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고농도(1 mg/mL) 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific LYRIC Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human Metadherin aa 18–253 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932438 |
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation and is overexpressed in breast cancer tissues and xenografts compared to normal breast tissue. Metadherin binds to lung vasculature, one of the common sites of breast cancer metastasis, via a C-terminal extracellular domain segment. Blocking this domain with antibodies or siRNA has been reported to inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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