Thermo Fisher Scientific mGluR5 (extracellular) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:400

-

Product Specifications

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide corresponding to amino acids 367-380 of rat mGluR5 (Extracellular, N-terminus) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:mGluR5,uniProtId:P31424-1,ncbiNodeId:10114,antigenRange:368-380,antigenLength:1203,antigenImageFileName:PA5-111826_mGluR5_P31424-1_Guinea_pig.svg,antigenImageFileNamePDP:PA5-111826_mGluR5_P31424-1_Guinea_pig_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2857235

Product Specific Information

Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Peptide sequence is: EGFAQENSKY NKTC

Homology: Mouse amino acid residues identical; human - 13/14 amino residues identical.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.