Thermo Fisher Scientific Phospho-CBX5 (Tyr37) Polyclonal Antibody
Phospho-CBX5 (Tyr37) 폴리클로날 항체로 인간, 마우스, 랫트에 반응. IHC, ICC, ELISA 등 다양한 응용 가능. Protein A로 정제된 고품질 항체이며, -20°C에서 안정적 보관 가능. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-CBX5 (Tyr37) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human CBX5 around the phosphorylation site of Tyr37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which act as heterochromatic adaptor molecules involved in gene silencing and chromatin structure formation. High-affinity recognition of methylated histone H3 by HP1 requires a functional chromodomain, serving as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, HP1 association with heterochromatin is lost in Suv39h double-mutant mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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