Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
인간 N4BP2L2 단백질에 특이적인 rabbit polyclonal 항체로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. DNA 손상 반응 및 골수 발현 연구에 적합.
- 카탈로그번호
- PA558786
- 판매단위
- pk
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Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:200–1:500
Publications: - [References pending]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human N4BP2L2. Recombinant protein control fragment (Product #RP-97967) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644415 |
Product Specific Information
Immunogen sequence:
KLAGPDSRGQ WIQMIFTSVA ASEPGNNPEI LTDKLLIGNE DFSPPPETMD SFIETNLFRS CLPQPDIPKN ALESTKNKKR RKKRIFNLVP NFDLLGQSRI GVKEREKCDL
Antigen sequence identity:
- Mouse: 22%
- Rat: 23%
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. It is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is down-regulated after exposure to arsenic compounds, preceding neutropenia. PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, which are implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased infection risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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