Thermo Fisher Scientific PER1 Polyclonal Antibody
PER1 단백질을 인식하는 토끼 폴리클로날 항체로, 사람 및 생쥐 시료에 반응합니다. Western blot 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼(20% 글리세롤) 용액 형태로 제공되며, 장기 보관 시 -20°C에서 보관하십시오.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human PER1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792728 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (97%), Rat (97%), Bovine (95%).
- Positive Control: 293T, A431, HeLa, PER1-transfected 293T.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Circadian rhythmicity is a fundamental property observed across diverse organisms, including animals, plants, and fungi. Regulation of endogenous biological clocks occurs at the genetic level through protein-mediated autoregulatory feedback loops.
In mammals, several genes encoding members of the basic helix-loop-helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family play a crucial role in circadian oscillations. Transactivation of CLOCK-induced genes is mediated via the E-box enhancer (CACGTG) located upstream of target genes. CLOCK-ARNT3 heterodimers bind to E-box elements to stimulate transcription.
The PER protein, together with the mammalian timeless gene (TIM) product, negatively regulates its own transcription by inhibiting the CLOCK-BMAL1 transactivation complex.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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