Thermo Fisher Scientific Ruplizumab Chimeric Recombinant Rabbit Monoclonal Antibody (hu5c8 (Ruplizumab))

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Flow Cytometry (Flow)

1 µg/mL

-

Inhibition Assays (IA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

hu5c8 (Ruplizumab)

Immunogen

Human CD40L

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3074410

Product Specific Information

Specificity: The antibody binds to CD40L with an IC50 of 0.845 µg/mL.

Target Information

Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive pharmaceutical and is a component of Antova. Ruplizumab is an anti-CD40L monoclonal antibody. The binding of CD40 to its ligand, CD40L is a critical element in T cell activation. In systemic lupus erythematosus, CD40L is over-expressed on T cells, B cells and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.