
Thermo Fisher Scientific Ruplizumab Chimeric Recombinant Rabbit Monoclonal Antibody (hu5c8 (Ruplizumab))
CD40L에 특이적으로 결합하는 재조합 토끼 단일클론 항체로, Western blot, Flow cytometry, Inhibition assay에 사용 가능. HEK293 세포에서 발현되며 Protein A로 정제됨. 연구용으로 면역억제 관련 연구에 적합.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Flow Cytometry (Flow) | 1 µg/mL | |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | hu5c8 (Ruplizumab) |
| Immunogen | Human CD40L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074410 |
Product Specific Information
- Specificity: The antibody binds to CD40L with an IC50 of 0.845 µg/mL.
Target Information
Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive pharmaceutical and is a component of Antova.
It is an anti-CD40L monoclonal antibody. The binding of CD40 to its ligand, CD40L, is a critical element in T cell activation.
In systemic lupus erythematosus, CD40L is over-expressed on T cells, B cells, and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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