Thermo Fisher Scientific EAAT4 Polyclonal Antibody
EAAT4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Protein A 정제 및 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human EAAT4 (amino acids 151–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Slc1a6 encodes a glutamate transporter, also known as an excitatory amino acid transporter (EAAT). These are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) and are widely distributed throughout the brain. There are five EAAT subtypes, each with specific distributions.
SLC1A6 functions as a sodium-dependent, high-affinity transporter mediating uptake of L-glutamate, L-aspartate, and D-aspartate. It operates as a symporter, co-transporting one amino acid molecule with two or three Na⁺ ions and one proton, while counter-transporting one K⁺ ion. It also mediates Cl⁻ flux to prevent negative charge accumulation during transport. SLC1A6 plays a role in rapid glutamate removal from the synaptic cleft, crucial for terminating postsynaptic glutamate action. Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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