Thermo Fisher Scientific RARA Monoclonal Antibody (763)
RARA 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 763). Western blot에 최적화되어 있으며, Human, Mouse, Rat에 반응. Protein G 정제, 보존제 무첨가, -20°C 보관. 연구용으로 적합.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 763 |
| Immunogen | Synthetic peptide corresponding to the N-terminal region of human RARA conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560878 |
Product Specific Information
- Predicted to react with bovine, canine, guinea pig, and mouse based on 100% sequence homology.
- Specific for the ~48 kDa RXR-1 protein.
Target Information
RARA (Retinoic Acid Receptor Alpha) is a receptor for retinoic acid. It forms heterodimers with RXR to bind retinoic acid response elements (RARE) and regulates gene expression in response to all-trans or 9-cis retinoic acid.
In the absence of ligand, RXR-RAR heterodimers associate with corepressors leading to chromatin condensation and transcriptional suppression. Upon ligand binding, corepressors dissociate and coactivators are recruited, resulting in transcriptional activation.
RARA is essential for retinoic acid-induced germ cell development during spermatogenesis, supports early spermatocyte survival, and contributes to skeletal growth and matrix homeostasis in cooperation with RARG. It also mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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