Thermo Fisher Scientific Human IGF1R, His Tag Recombinant Protein
인간 IGF1R His-tag 재조합 단백질로, Baculovirus 시스템에서 발현된 정제된 액상 단백질입니다. 키나아제 분석에 적합하며, -80°C 보관 시 안정적입니다. 연구용으로만 사용 가능하며 다양한 암 연구 및 신호전달 경로 분석에 활용됩니다.
- 카테고리
- Protein
- 판매단위
- pk
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Thermo Fisher Scientific Human IGF1R, His Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution
- Assay-dependent
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Baculovirus |
| Amino Acid Sequence | 960–1397 |
| Tag | His-tag |
| Molecular Weight | 48.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris (pH 7.5), 0.05% Triton X-100, 50% glycerol, 100 mM NaCl, 2 mM DTT, 0.05 mM EDTA |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
- For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
- Never store kinase diluted.
- Properly stored at -80°C, product stability guaranteed for 6 months from purchase date.
- Protein Form: Cytoplasmic
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers. The protein forms a tetramer with two alpha and two beta subunits. The alpha-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at positions 1134, 1135, and 1136. Activated IGF1R phosphorylates substrate proteins, triggering RAS, RAF, and MAPK pathways (ERK, p38, JNK), leading to gene transcription and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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