Thermo Fisher Scientific Human IGF1R, His Tag Recombinant Protein

Thermo Fisher Scientific Human IGF1R, His Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Publications

• [References not provided]

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, product stability guaranteed for 6 months from purchase date.
• Protein Form: Cytoplasmic

Target Information

IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers. The protein forms a tetramer with two alpha and two beta subunits. The alpha-subunits bind IGF-1 with higher affinity than IGF-2, inducing conformational change and autophosphorylation at positions 1134, 1135, and 1136. Activated IGF1R phosphorylates substrate proteins, triggering RAS, RAF, and MAPK pathways (ERK, p38, JNK), leading to gene transcription and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.