Thermo Fisher Scientific RHD Polyclonal Antibody

Thermo Fisher Scientific RHD Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:1,000
Publications: -

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

The Rhesus (Rh) blood group system is one of the most complex and important systems in humans. Two highly homologous genes, RHD and RHCE (collectively referred to as RH30 or RHCED), encode the antigens of the Rh blood group system. These genes map to human chromosomal position 1p34.1–1p36.

The RHD gene, often deleted in a large portion of the population, encodes the potent D antigen, a major blood group immunogen. Rh incompatibility between maternal and fetal blood types can result in hemolytic disease of the newborn (HDN), which may lead to fetal death. The RHCE gene exists in four allelic forms, determining expression of Ce, ce, cE, or CE antigen combinations.

RHCED antigens are integral membrane proteins with 12 transmembrane helices that maintain erythrocyte membrane integrity. Proper presentation of Rh antigenic activity requires a complex formation between RHCED antigens and RHAG (RH50).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 또는 제거됨)