Thermo Fisher Scientific KI67 Monoclonal Antibody (UMAB107), UltraMAB
인간 Ki-67 단백질을 인식하는 마우스 단클론 항체로 세포 증식 마커 연구에 적합함. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 친화 크로마토그래피 정제 및 안정적 액상 형태 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific KI67 Monoclonal Antibody (UMAB107), UltraMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Miscellaneous PubMed (Misc) | - |
Publications: View 11 publications
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB107 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly in late G1, S, G2, and M phases. It contains a forkhead-associated (FHA) domain that enables association with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus. Ki-67 shows cell cycle-dependent topographical distribution: perinucleolar expression at G1, nuclear matrix expression at G2, and chromosomal localization during M phase.
Ki-67 is widely used as a proliferation marker since it is absent in G0 cells and increases steadily from G1 through mitosis. Ki-67 antibodies help determine the cell growth fraction in neoplasms, with prognostic value comparable to the tritiated thymidine-labelling index. Low Ki-67 index correlates strongly with histologically low-grade tumors. It is routinely used as a neuronal marker for cell cycling and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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