Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ESR1/1935)
에스트로겐 의존성 마커로 사용되는 인간 에스트로겐 수용체 알파(ESR1) 단클론 항체. Western blot 및 면역조직화학(IHC)에 적합. 단클론(Mouse IgG2a) 형태로 제공되며, 액상 제품으로 4°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESR1/1935 |
| Immunogen | Recombinant full-length human Estrogen Receptor alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription through recruitment of coactivator or corepressor proteins.
There are two forms of the estrogen receptor: alpha (ESR1) and beta (ESR2), encoded by separate genes. Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed in various tissues and are essential for sexual development, reproductive function, and bone maintenance. They are also implicated in pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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