Thermo Fisher Scientific C6orf57 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human C6orf57. Recombinant protein control fragment (Product #RP-94909). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C6orf57,uniProtId:Q5VUM1-1,ncbiNodeId:9606,antigenRange:23-107,antigenLength:108,antigenImageFileName:PA5-56871_C6orf57_Q5VUM1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56871_C6orf57_Q5VUM1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639121

Product Specific Information

Immunogen sequence: SPLLCHSLRK TSSSQGGKSE LVKQSLKKPK LPEGRFDAPE DSHLEKEPLE KFPDDVNPVT KEKGGPRGPE PTRYGDWERK GRCID

Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 78%.

Target Information

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.