Thermo Fisher Scientific Complement C5b-9 Monoclonal Antibody (3R2/0)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis-inducing C5b-9 complex.

Target Information

The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in immune defense. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis.

MAC is involved not only in antimicrobial defense but also in mediating cell death in pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three major loci. Understanding the C5b-9 complex extends beyond its immune role to its interactions with tumor cells, where it can induce cell death and influence cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.