Thermo Fisher Scientific CD40 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize isoform 1 (NP_001241.1) only.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

The CD40 antigen is a single-chain glycoprotein and a member of the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin's disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells, and also found on some epithelial cells, carcinomas, and lymphoid dendritic cells.
CD40 plays a crucial role in immune and inflammatory responses, including:

• T cell-dependent immunoglobulin class switching
• Memory B cell development
• Germinal center formation

AT-hook transcription factor AKNA regulates CD40 expression, facilitating homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction.
The CD40-CD40L interaction is essential for amyloid-beta-induced microglial activation, implicated in Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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