Thermo Fisher Scientific ETS1 Polyclonal Antibody
ETS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, Flow cytometry에 적합. 인간 반응성, 마우스 및 랫트에 예측 반응. Protein A 및 항원 친화 크로마토그래피로 정제된 액상형 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 43–70 amino acids from the N-terminal region of human ETS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541711 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein and a member of the DNA-binding ETS family. It contains an N-terminal pointed domain, a central transactivation domain, and two auto-inhibitory domains flanking the C-terminal Ets domain.
ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, mediating transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase. Activated by Ras/MAPK signaling, ETS1 expression is upregulated in resting T-cells.
Its activity is modulated by AP-1, Sp-1, c-myb, and MafB. Sp100 activates ETS1 in nuclear bodies, while interactions with EAP1/Daxx repress MMP1 and BCL2 transactivation. ETS1 also interacts with STAT6 to modulate Socs-1 expression induced by IL-4 and with GATA3 to positively regulate Tax-1-dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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