Thermo Fisher Scientific FKBP15 Polyclonal Antibody
FKBP15 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, Western blot과 IHC(P)에서 검증됨. 인간 시료에 반응하며, 고순도 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FKBP15. Recombinant protein control fragment (Product #RP-89625). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641653 |
Product Specific Information
Immunogen sequence:
KHSAGNSMLI PSMSVTMETS MIMSNIQRII QENERLKQEI LEKSNRIEEQ NDKISELIER NQRYVEQSNL MMEKRNNSLQ TATENTQARV LHAEQEKAKV TEELAAATAQ VSHLQLKMTA HQ
Ortholog sequence identity:
- Mouse: 95%
- Rat: 94%
Target Information
FKBP15 (also known as FKBP133) is a member of the FK506-binding protein family, initially identified as immunophilins and targets for the immunosuppressant drugs FK506 and Rapamycin.
FKBP15 is expressed in the developing nervous system and contains a WH1 domain similar to Wiskott-Aldrich syndrome protein homology region 1, in addition to the FK506-binding motif.
It is distributed along axonal shafts and partially co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression increases filopodia formation, suggesting a role in growth cone behavior.
FKBP15 associates with microtubules and actin filaments, and its knockdown by RNAi delays early endosome transport in HeLa cells, indicating involvement in endosomal transport.
At least three isoforms of FKBP15 are known.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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