Thermo Fisher Scientific MEF2B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: [References not provided]

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500
• Publications: [References not provided]

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total MEF2B.

Target Information

The myocyte enhancer factor-2 (MEF-2) family of transcription factors associates with co-repressors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells.
Four family members arise from alternatively spliced transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF-2D.
These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes.
Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development.
The differentiation process from mesodermal precursor cells to myoblasts has led to the discovery of various tissue-specific factors that regulate muscle gene expression.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.