Thermo Fisher Scientific Urokinase Monoclonal Antibody (PGM2001)
Thermo Fisher Scientific의 Urokinase Monoclonal Antibody (PGM2001)는 인간 요로키나아제에 특이적인 Mouse IgG1 단일클론 항체입니다. Western blot, IHC(F), ELISA, RIA 등 다양한 분석에 사용 가능하며, 동결건조 형태로 제공되어 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:30–1:50 |
| ELISA | 1:5,000 |
| Radioimmune Assay (RIA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PGM2001 |
| Immunogen | Human urinary urokinase |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1088177 |
Product Specific Information
Reconstitute with 1 mL of distilled water and add preservative if preferred.
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation.
A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and decreased affinity for fibrin-binding.
This protein converts plasminogen to plasmin by cleavage of an Arg-Val bond in plasminogen. Plasmin further cleaves this protein at a Lys-Ile bond to form a two-chain derivative (HMW-uPA), which can be processed into LMW-uPA.
LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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